Immuno-enhancement of barely β-glucan or barley extracts on arsenic trioxide-induced immunosuppressed rat model

Document Type : Original Research

Author

Special Food and Nutrition Dept., Food Technology Research Institute, Agric. Res. Center, Giza, Egypt

Abstract

The present investigation aimed to study the biological effects of barely βglucan or barley extracts on arsenic trioxide-induced immunosuppression. Fiftyfour male albino rats (weighing 100±25 g) were divided into eight groups, each 
group including six rats. Group 1: PBS was injected intraperitoneally into the rats, 
while saline was given orally (negative control). Groups 2–8 received daily 
intraperitoneal injections of As2O3 (5 mg/kg) for 4 weeks. Group 2 serves as a 
positive control. The rats in groups 3, 4, and 5 were received daily doses of βglucan extracts of 40, 80, and 160 mg/kg bw/day, respectively, with ATO (arsenic 
trioxide). Groups 6, 7, and 8 were given barley extract at doses of 0.7, 1.4, and 2.8 
g/kg bw/day, respectively, with ATO. At the end of the experiment, all of the rats 
were slaughtered for biochemical, hematological, and histopathological analysis. 
The obtained results revealed that barley β-glucan and barley extracts increased 
CAT and GPx activity while lowering MDA levels in the spleen tissue of rats. 

Keywords

International Journal of Family Studies, Food Science and Nutrition Health
Volume 3, Issue 2
December 2022
Pages 1-39

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